gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Aztreonam binds bacterial PBP3 (FtsI) and blocks peptidoglycan cross-linking, disrupting cell wall synthesis and causing osmotic lysis and death of the bacteria.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary target in gram-negative bacteria (e.g., Pseudomonas aeruginosa) involved in peptidoglycan cross-linking
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06159725
disease_id_num_tar_ref
349
drug_id_num_tar_ref
1002