gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-MET ADC binds MET on target cells, is internalized, and releases MMAE intracellularly; MMAE inhibits tubulin polymerization causing G2/M arrest and apoptosis of MET-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05821933
disease_id_num_tar_ref
4068
drug_id_num_tar_ref
10965