gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC108 targets MET, is internalized, and releases MMAE that binds tubulin to disrupt microtubules, causing G2/M arrest and apoptosis; tubulin expression alone does not make cells targets—only MET-positive cells are killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds Vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05821933
disease_id_num_tar_ref
4068
drug_id_num_tar_ref
10965