gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible covalent inhibition of mutant EGFR (including T790M) blocks survival signaling (e.g., MAPK/PI3K-AKT), causing apoptosis of EGFR-mutant tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Third-generation irreversible covalent kinase inhibitor; binds ATP site (Cys797) with selectivity for mutant EGFR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05821933
disease_id_num_tar_ref
4068
drug_id_num_tar_ref
10966