gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Small‑molecule TKI inhibits mutant EGFR (including T790M), blocking downstream survival/proliferation signaling (e.g., MAPK/PI3K-AKT) and inducing apoptosis of EGFR T790M–positive tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Selectively inhibits the T790M gatekeeper mutant; irreversible covalent binding to Cys797
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05821933
disease_id_num_tar_ref
4068
drug_id_num_tar_ref
10966