gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused autologous CD8+ TILs recognize the tumor neoantigen peptide–HLA class I complex via their endogenous TCR and directly kill target cells through HLA-restricted cytotoxicity (perforin/granzyme release and death receptor pathways).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Patient-specific mutated peptide presented on HLA-A/B/C; recognized by endogenous TCRs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05902520
disease_id_num_tar_ref
4070
drug_id_num_tar_ref
10969