gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Endogenous TCRs on reinfused CD8+ TILs recognize tumor-associated peptide–HLA class I (pMHC), triggering cytotoxic T-cell killing via perforin/granzyme release and death receptor pathways (e.g., Fas–FasL), HLA-I–restricted.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Includes non-mutated differentiation or cancer-testis antigen peptides presented on HLA-A/B/C; recognized by endogenous TCRs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05902520
disease_id_num_tar_ref
4070
drug_id_num_tar_ref
10969