gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells and engages Fcγ receptor–bearing effector cells to mediate ADCC, leading to killing of HER2+ cells (with possible contribution from CDC and apoptosis).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of HER2; inhibits HER2 signaling and receptor shedding; mediates ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06135714
disease_id_num_tar_ref
4071
drug_id_num_tar_ref
10978