gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases the topoisomerase I inhibitor DXd, causing DNA damage, replication arrest, and apoptosis; Fc-mediated ADCC and a membrane-permeable payload enable additional bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07030569
disease_id_num_tar_ref
354
drug_id_num_tar_ref
1013