gene_symbol
FAS
hgnc_id
HGNC:11920
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
iNKT cells express FasL and engage Fas (CD95) on target cells, triggering death receptor–mediated (caspase-8) apoptosis; they can also kill via perforin/granzyme.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by Fas ligand (FASLG) on iNKT cells to induce apoptosis
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05962450
disease_id_num_tar_ref
4088
drug_id_num_tar_ref
11028