gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Teclistamab crosslinks CD3 on T cells to BCMA on target cells, activating T cells to kill BCMA+ cells via perforin/granzyme release and cytokine-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TNF receptor superfamily member; plasma cell antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05972135
disease_id_num_tar_ref
4091
drug_id_num_tar_ref
11039