gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HS-20089 binds B7-H4 on tumor cells, is internalized, and releases a TOP1 inhibitor that traps TOP1–DNA complexes, causing DNA damage and apoptosis in B7-H4–expressing cells; DNA topoisomerase I is not the antigen targeted for cell selection.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target; inhibitor stabilizes DNA–TOP1 cleavable complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06014190
disease_id_num_tar_ref
4095
drug_id_num_tar_ref
11046