gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin targets HER2, is internalized, and releases MMAE that binds the beta-tubulin (vinca) site to disrupt microtubules, causing G2/M arrest and apoptosis. Beta-tubulin is not the directly targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Cytotoxic payload MMAE binds β-tubulin at the vinca domain to inhibit microtubule polymerization.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05980481
disease_id_num_tar_ref
4101
drug_id_num_tar_ref
11064