gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After binding HER2, trastuzumab engages Fcγ receptors on immune effector cells to trigger ADCC (primarily NK-cell–mediated; also ADCP/CDC), killing HER2+ cells; signaling blockade may also promote apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (subdomain IV) of the HER2 receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05980481
disease_id_num_tar_ref
4101
drug_id_num_tar_ref
11065