gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and engages Fcγ receptor–bearing effector cells to mediate antibody-dependent cellular cytotoxicity (ADCC), killing HER2+ cells; HER2 signaling inhibition can further promote apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV of HER2; blocks signaling and mediates ADCC via Fcγ receptor–bearing effector cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05983094
disease_id_num_tar_ref
4110
drug_id_num_tar_ref
11091