gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds the HER2 subdomain II, recruits FcγR-expressing immune effectors (e.g., NK cells) to mediate ADCC, killing HER2+ cells; it also blocks HER2 heterodimerization, suppressing survival signaling and promoting apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks HER2 heterodimerization (especially with HER3) and mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05983094
disease_id_num_tar_ref
4110
drug_id_num_tar_ref
11092