gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds MET on target cells and its IgG1 Fc engages FcγR-expressing effector cells (e.g., NK cells/macrophages) to mediate ADCC/ADCP, killing MET-expressing cells; it also downregulates MET/EGFR signaling.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor tyrosine kinase; extracellular domain binding; inhibits phosphorylation; promotes receptor downregulation; enables Fc-mediated ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05663866
disease_id_num_tar_ref
4112
drug_id_num_tar_ref
11100