gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mutant-selective, irreversible inhibition of EGFR L858R kinase activity (covalent binding) blocks MAPK/PI3K-AKT signaling, triggering apoptosis of EGFR-mutant tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Covalent inhibition at kinase domain cysteine (Cys797); mutant-selective high potency
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05663866
disease_id_num_tar_ref
4112
drug_id_num_tar_ref
11101