gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mutant-selective, irreversible inhibition of EGFR T790M blocks downstream MAPK/PI3K signaling, causing growth arrest and apoptosis of EGFR T790M–positive tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Covalent inhibition at kinase domain cysteine (Cys797); targets gatekeeper resistance mutation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05663866
disease_id_num_tar_ref
4112
drug_id_num_tar_ref
11101