gene_symbol
TNFRSF9
hgnc_id
HGNC:11924
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
FT522 NK cells express an alloimmune defense receptor that binds 4-1BB (CD137) on activated alloreactive host immune cells, triggering NK activation and direct killing via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alloimmune defense receptor (ADR) target on activated alloreactive host immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05950334
disease_id_num_tar_ref
4116
drug_id_num_tar_ref
11106