gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FT522’s CD16 binds the Fc of therapeutic IgG1 antibodies that are bound to their true antigen on tumor cells, triggering NK-cell ADCC to kill the antigen-expressing cells; the IgG1 Fc itself is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc of therapeutic antibodies (e.g., rituximab) engaged by hnCD16 to mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05950334
disease_id_num_tar_ref
4116
drug_id_num_tar_ref
11106