gene_symbol
NECTIN4
hgnc_id
HGNC:19688
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds Nectin-4, is internalized, and releases MMAE, which disrupts microtubules (tubulin inhibition), causing G2/M arrest and apoptotic death of Nectin-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface adhesion molecule; ADC internalization enables MMAE release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05614739
disease_id_num_tar_ref
4118
drug_id_num_tar_ref
11117