gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-targeted ADC binds HER2, is internalized, and releases MMAE via protease-cleavable linker; MMAE disrupts microtubules causing G2/M arrest and apoptosis. Fc-mediated ADCC may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; ADC antibody target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06385873
disease_id_num_tar_ref
32
drug_id_num_tar_ref
80