gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Glofitamab engages CD3ε on T cells to activate them; the activated T cells kill CD20-positive B cells via perforin/granzyme-mediated cytotoxicity, not the CD3ε-expressing T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
monovalent binding (2:1 CD20:CD3 format)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06534437
disease_id_num_tar_ref
364
drug_id_num_tar_ref
1041