gene_symbol
PRAME
hgnc_id
HGNC:9336
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The TCER binds the PRAME peptide–HLA class I complex on tumor cells and CD3 on T cells, forming an immune synapse that activates T cells to kill target-expressing cells via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
PRAME-derived peptide presented by HLA class I; specific allele not specified
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05958121
disease_id_num_tar_ref
4147
drug_id_num_tar_ref
11210