gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3 on T cells to recruit and activate them; activated T cells then kill PRAME/HLA-positive tumor cells via perforin/granzyme. CD3+ cells are not targeted for killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 complex on T cells engaged by anti-CD3 moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05958121
disease_id_num_tar_ref
4147
drug_id_num_tar_ref
11210