gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD33-specific CAR T cells bind CD33 on target cells and induce T-cell cytotoxicity via perforin/granzyme release and death-receptor signaling (e.g., Fas/TRAIL), leading to apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
also known as Siglec-3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05942599
disease_id_num_tar_ref
4149
drug_id_num_tar_ref
11214