gene_symbol
CD52
hgnc_id
HGNC:1804
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Alemtuzumab binds CD52 on lymphocytes and triggers Fc-mediated killing via ADCC (NK cells/macrophages) and complement-dependent cytotoxicity (CDC), and can induce apoptosis of the bound cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein on mature T and B lymphocytes; also present on some NK cells and monocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06100965
disease_id_num_tar_ref
4153
drug_id_num_tar_ref
11219