gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and its Fc engages Fcγ receptors on NK cells, triggering antibody‑dependent cellular cytotoxicity (ADCC) that kills HER2+ cells; signaling blockade may also promote apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06016387
disease_id_num_tar_ref
4160
drug_id_num_tar_ref
11232