gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific antibody binds GPRC5D on tumor cells and CD3 on T cells, forming an immune synapse that activates T-cell cytotoxicity (perforin/granzyme-mediated killing) of GPRC5D-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPCR on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05920876
disease_id_num_tar_ref
4162
drug_id_num_tar_ref
11236