gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 on T cells is engaged to activate and redirect T cells, which then kill GPRC5D+ myeloma cells via immune synapse formation and perforin/granzyme-mediated lysis; CD3+ cells themselves are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 complex on T cells (epsilon subunit binder typical for T-cell engagers)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05920876
disease_id_num_tar_ref
4162
drug_id_num_tar_ref
11236