gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific anti-PSMA×CD28 antibody provides localized CD28 co-stimulation on T cells at PSMA+ cells, activating/expanding T cells that then kill PSMA-expressing cells via cytotoxic T-cell mechanisms (perforin/granzyme, Fas–FasL).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on prostate cancer cells; binding localizes/conditions CD28 co-stimulation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06085664
disease_id_num_tar_ref
4173
drug_id_num_tar_ref
11254