gene_symbol
CD28
hgnc_id
HGNC:1653
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds CD28 on T cells to provide co-stimulation only when also bound to PSMA on tumor cells, activating T cells to lyse PSMA-positive tumor cells (perforin/granzyme, cytokines). CD28-expressing cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Conditional CD28 agonist co-stimulation delivered upon co-binding with PSMA; expressed on T lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06085664
disease_id_num_tar_ref
4173
drug_id_num_tar_ref
11254