gene_symbol
TGFB2
hgnc_id
HGNC:11768
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR T cells kill GPC3-positive cells via perforin/granzyme. The dominant-negative TGF-beta receptor blocks TGF-beta2 signaling in the CAR T cells and does not cause direct killing of TGF-beta2–expressing cells (unless they also express GPC3).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ligand bound by dominant-negative TGFBR2 expressed on CAR T cells to block TGF-β signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06084884
disease_id_num_tar_ref
4178
drug_id_num_tar_ref
11265