gene_symbol
TGFB3
hgnc_id
HGNC:11769
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AZD5851 CAR-T cells target GPC3, not TGF-β3. The dnTGFβRII armors T cells by blocking TGF-β signaling without inducing killing of TGF-β3–expressing cells. Cytotoxicity is only against GPC3+ cells via perforin/granzyme after CAR engagement.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ligand bound by dominant-negative TGFBR2 expressed on CAR T cells to block TGF-β signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06084884
disease_id_num_tar_ref
4178
drug_id_num_tar_ref
11265