gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells and depletes them via enhanced Fc gamma RIIIa–mediated ADCC (NK cells/monocytes) and induction of type II, caspase-independent direct cell death; complement lysis is relatively reduced.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding; induces direct cell death and Fc-mediated ADCC with relatively reduced CDC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06094881
disease_id_num_tar_ref
4194
drug_id_num_tar_ref
11308