gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16b is an Fc receptor on neutrophils. Obinutuzumab binds CD20 on B cells and engages CD16 (including CD16b) via its Fc to recruit ADCC/ADCP, plus induces direct type II cell death of CD20+ cells; CD16b+ cells are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-dependent effector engagement; increased affinity due to glycoengineering
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06094881
disease_id_num_tar_ref
4194
drug_id_num_tar_ref
11308