gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ipilimumab binds CTLA-4 on T cells (especially intratumoral Tregs) and, via its IgG1 Fc, engages Fc receptor–bearing effector cells (e.g., NK cells, macrophages) to mediate ADCC/ADCP, depleting CTLA-4–positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CTLA-4 interaction with CD80/CD86; IgG1 Fc may mediate Treg depletion via Fc-effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06159101
disease_id_num_tar_ref
4195
drug_id_num_tar_ref
11310