gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases the topoisomerase I inhibitor deruxtecan inside HER2+ cells, causing DNA damage and apoptosis; the antibody Fc can also trigger ADCC.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab moiety binds extracellular domain IV of HER2; ADC internalization required
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05900206
disease_id_num_tar_ref
4198
drug_id_num_tar_ref
11314