gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 and recruits Fcγ receptor–bearing immune cells to induce ADCC against HER2+ cells; it also blocks HER2/HER3 signaling, promoting apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain II (dimerization arm) to block HER2/HER3 dimerization; Fc mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05900206
disease_id_num_tar_ref
4198
drug_id_num_tar_ref
11319