gene_symbol
SIGLEC2
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD22 ADC binds CD22, is internalized, and releases calicheamicin that induces DNA double‑strand breaks, leading to apoptosis of CD22+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; internalization enables intracellular payload delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05748171
disease_id_num_tar_ref
4204
drug_id_num_tar_ref
11338