gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on the cell surface; its IgG1 Fc engages Fcγ receptors on NK cells to trigger antibody‑dependent cellular cytotoxicity (ADCC), killing PD‑L1–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binding blocks PD-L1 interaction with PD-1 (PDCD1) and B7.1 (CD80); Fc-competent IgG1 can enable NK-cell–mediated ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05650164
disease_id_num_tar_ref
4213
drug_id_num_tar_ref
11360