gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and triggers Fc-mediated effector functions—complement-dependent cytotoxicity (CDC), NK-cell antibody-dependent cellular cytotoxicity (ADCC), and macrophage antibody-dependent cellular phagocytosis (ADCP)—killing CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NAD+ glycohydrolase/ADP-ribosyl cyclase) on plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05641324
disease_id_num_tar_ref
4232
drug_id_num_tar_ref
11418