gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The tri-specific NK cell engager binds CD123 on target cells and NKp46/CD16 on NK cells, bringing them together and activating NK cells to degranulate (perforin/granzymes) and lyse CD123-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on leukemic cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508489
disease_id_num_tar_ref
4252
drug_id_num_tar_ref
11492