gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The HER2-targeted ADC is internalized into HER2+ cells and releases MMAE, which binds the vinca domain on β-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis; released MMAE can also produce a bystander killing effect.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular target of MMAE payload; inhibition of microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06015113
disease_id_num_tar_ref
4253
drug_id_num_tar_ref
11495