gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-EGFR IgG1 mAb binds EGFR on target cells, blocks survival signaling (promoting growth arrest/apoptosis) and recruits FcγR+ effector cells to mediate ADCC against EGFR-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; blocks ligand binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06988956
disease_id_num_tar_ref
4256
drug_id_num_tar_ref
11506