gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48 targets HER2, is internalized, and releases MMAE, which binds tubulin to disrupt microtubules causing G2/M arrest and apoptosis. Killing is driven by HER2-mediated delivery (with possible bystander effect), not by recognition of tubulin itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06385873
disease_id_num_tar_ref
32
drug_id_num_tar_ref
80