gene_symbol
TIGIT
hgnc_id
HGNC:26838
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 Fc engages Fc-gamma receptor effector cells (e.g., NK cells, macrophages) to mediate ADCC/ADCP (and possibly CDC), depleting TIGIT-expressing regulatory T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint receptor; blocking TIGIT–CD112/CD155 interactions shifts signaling toward CD226 co-stimulation; Fc effector may deplete TIGIT+ Tregs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05718219
disease_id_num_tar_ref
4258
drug_id_num_tar_ref
11513