gene_symbol
PVRIG
hgnc_id
HGNC:32190
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc-mediated effector function (ADCC/ADCP) can deplete PVRIG-expressing (TIGIT+) regulatory T cells bound by the antibody; effector T/NK cells are activated rather than depleted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint receptor for CD112; also known as CD112R
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05718219
disease_id_num_tar_ref
4258
drug_id_num_tar_ref
11513