gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on tumor cells and its IgG1 Fc engages FcγR-bearing effector cells to trigger ADCC (and sometimes complement-mediated cytotoxicity), causing target-cell lysis; it also blocks EGFR signaling (primarily cytostatic).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular ligand-binding domain; blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06447662
disease_id_num_tar_ref
4283
drug_id_num_tar_ref
11584